In conclusion, the AgLTF-DsiRNA-loaded hydrogel possessed antibacterial, anti-biofilm, and pro-migratory activities. The hydrogels containing DsiRNA and LTF demonstrated superior pro-migratory effects compared to the control group. The hydrogel containing AgLTF at 125 µg/mL was also non-cytotoxic on HaCaT cells for up to 72 h of incubation. The hydrogels demonstrated positive antibacterial and anti-biofilm effects toward the selected Gram-positive and Gram-negative bacteria. The formed hydrogels exhibited 1668% maximum swellability, with a 46.67 ± 10.33 µm average pore size. In this study, AgNPs were complexed with LTF and DsiRNA via simple complexation before packaging in gelatin hydrogels. Silver nanoparticles (AgNPs) and lactoferrin (LTF) have been investigated as alternative antimicrobial and anti-biofilm agents, respectively, while dicer-substrate short interfering RNA (DsiRNA) has also been studied for its wound healing effect in diabetic wounds. Therefore, this study aimed to develop a dressing that could effectively aid in the wound healing process and prevent bacterial infections by exerting both antibacterial and anti-biofilm effects. Contact us for more details or sign up for our platform today.Antimicrobial resistance and biofilm formation in diabetic foot infections worsened during the COVID-19 pandemic, resulting in more severe infections and increased amputations. Start using Foxit’s free PDF Reader today to find out why it’s the leading PDF Reader tool in the industry. Our PDF Reader tool is effective, fast, and easy to use for all purposes, making it the best option for students, business professionals, enterprise companies, and more. Why Choose Foxit?įoxit offers the industry’s most robust PDF technology and hundreds of thousands of users prefer it over others. To create PDFs, you can use Foxit’s PDF Reader to upload scans or convert Word documents, Powerpoint presentations, and Excel sheets. To start using the Foxit PDF Reader today, simply download the Foxit PDF Reader to your device and start using it! Get the most out of our robust PDF Reader tool by uploading, creating, sharing, and securing your PDFs. Plus, it integrates with Enterprise Content Management systems and cloud storage services, making it an ideal solution. Our PDF Reading tool is designed to meet the needs of individual, enterprise, and government organizations.

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